Department of Image Processing

The seminar starts at 11:15.

MVDr. Štefan Juhás, Ph.D.
Institute of Animal Physiology and Genetics of the ASCR

Huntington´s disease - miniature pig Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion in polyQ repeat in the huntingtin (HTT) protein. Pig represents a suitable model for neurological diseases because of its large gyrencephalic brain with a primate-like neuroarchitecture and long lifespan. Here we have generated HD transgenic (tgHD) minipigs using microinjection of lentiviral constructs encoding the first 548aa of human mutant HTT under the control of human HTT promoter into the one-cell stage porcine embryos...